Neural network importance chart showing…, Fig 4. Mean (SE) z scores of Consortium to Establish a Registry for Alzheimer’s disease…, Fig 3. For more information about PLOS Subject Areas, click S3 Fig shows the results of this Multilayer Perceptron Neural Network analysis with network information, model summary, parameter estimates, and input variable importances. Consistently, females perform better than males on episodic memory tasks including delayed recall and recognition. In our study, increasing age is accompanied by lowered VFT, BNT and MMSE scores, which are also the key features of aMCI, suggesting that accelerated ageing in processes that mediate language and executive-semantic functions play an important role in aMCI. Front Hum Neurosci. These results show that impairments in episodic memory, immediate working memory and recall are characteristic features of deficit schizophrenia, whilst dysnomia is a feature of aMCI. No, Is the Subject Area "Neural networks" applicable to this article? Data access requests can be submitted to the Department of Psychiatry Data Access Committee (psych.researchdata@chula.ac.th). Yes Results of GLM and logistic regression analyses, linear SVM, Random Forest and Neural Networks agreed that deficit schizophrenia is well-separated from aMCI patients by lowered WLM and MMSE test scores and higher false recall scores, while patients with aMCI show lower BNT scores. COVID-19 is an emerging, rapidly evolving situation. Episodic Memory and Trauma Episodic memory has to do with how you remember specific events, including traumatic memories. Verbal episodic memory was assessed using Delayed Recall from the Free and Cued Selective Reminding Test (FCSRT). Towards this end we recruited 60 participants with aMCI, 40 with deficit and 40 with nondeficit schizophrenia and 103 normal volunteers. For example, it is common to assess short-term memory span and delayed episodic memory ability. WLcorrect1: Trial 1 (WLM correct 1); WLcorrect2: Trial 2 (WLM correct 2); WLcorrect3: Trial 3 (WLM correct 3); WLM: Word List Memory, total score. https://doi.org/10.1371/journal.pone.0197004.t002. Visualization, Competing Interests: The authors have declared that no competing interests exist. Citation: Kanchanatawan B, Tangwongchai S, Supasitthumrong T, Sriswasdi S, Maes M (2018) Episodic memory and delayed recall are significantly more impaired in younger patients with deficit schizophrenia than in elderly patients with amnestic mild cognitive impairment. Tests were two-tailed and a p-value of 0.05 was used for statistical significance. However, no research has directly compared these putative differences in cognitive profiles between individuals with (non)deficit schizophrenia and aMCI using the CERAD-NP battery. 2020 Mar;30(1):97-125. doi: 10.1007/s11065-020-09428-6. Anatomical comparison of the hippocampus (avian hippocampus), parahippocampal region (avian area ... after the social encounter,but no memory when the test is delayed by 24 hours (FIG.4)33,76.The observation ofintact short-term memory is … Arch Neurol. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Since the healthy control group consisted of a younger subsample (age-matched to schizophrenia patients) and an elderly subsample (age-matched to aMCI patients) the total control group showed an intermediate age. Project administration, Affiliation Tests for between-subject effects showed significant effects on VFT (F = 22.65, df = 3/238, p<0.001, partial eta-squared = 0.222), BNTm (F = 9.20, df = 3/238, p<0.001, partial eta-squared = 0.104), BNTl (F = 21.29, df = 3/238, p<0.001, partial eta-squared = 0.212), BNT total (F = 19.44, df = 3/238, p<0.001, partial eta-squared = 0.197), and MMSE (F = 22.65, df = 3/238, p<0.001, partial eta-squared = 0.222). In order to define the correlations between education and the CERAD test scores we have computed the intercorrelation matrix between the two variables in normal controls. BNTtotal: Boston naming Test, total score; WLM: Word List Memory; WLTRueRecall: Word List Recall, Delayed, true recall; WLRecognition: Word List Recognition, total score; WLFalse Recall: Word List Recall, Delayed, false recall; VFT: Verbal Fluency Test; MMSE: Mini Mental State Examination. Data Availability: There are restrictions on publicly sharing the dataset, as a result of the informed consent given by the study participants, which has been approved by the Institutional Review Board (IRB) Faculty of Medicine Chulalongkorn University (http://www.medchulairb.com/ethics). Language deficits including poor naming performance are early and important diagnostic criteria for MCI [16,34,35]. Yes There was a highly significant effect of diagnostic groups (F = 11.41, df = 9/577, p<0.001) explaining 12.4% of the variance in the data. Schizophrenia patients were diagnosed according to DSM-IV-TR criteria and the diagnosis of deficit schizophrenia was made according to The Schedule for the Deficit Syndrome [20]. Table 5 shows the results of 10-fold cross-validation and predictive weights or importances of the CERAD variables in Linear SVM and Random Forest Models separating aMCI from deficit or nondeficit schizophrenia. here. Aniwattanapong D, Tangwongchai S, Supasitthumrong T, Hemrunroj S, Tunvirachaisakul C, Tawankanjanachot I, Chuchuen P, Snabboon T, Carvalho AF, Maes M. Aging Ment Health. Mean (SE) z scores of Consortium to Establish a Registry for Alzheimer’s disease…, Fig 2. Both stories were administered, each containing 25 elements, … Copyright: © 2018 Kanchanatawan et al. This suggests that higher education could constitute a protective factor against the cognitive decline occurring in patients with aMCI and (non)deficit schizophrenia. The latter study sample shows an age range of 20 to 83 years, and therefore comprises an unrestricted sample that allows us to examine the effects of age on the CERAD test scores. Measures The measures of cognitive ability in the HRS are the out-comes of simple tests (e.g., immediate and delayed word recall (episodic memory), serial 7’s, backward count start-ing from 20, and date naming). 2012 Feb 28;201(2):159-67. doi: 10.1016/j.pscychresns.2011.06.007. Writing – original draft, Affiliation PLoS ONE 13(5): Imagine that you get a phone call from an old college friend. https://doi.org/10.1371/journal.pone.0197004.s001. Sophie Dupont, ... (fMRI) study, we suggested that in left medial temporal lobe epilepsy (LTLE) poor verbal episodic memory performances were sustained by abnormal neocortical and mesiotemporal activations. Cognitive measures were assessed with the Consortium to Establish a Registry for Alzheimer's disease (CERAD) using the Verbal Fluency Test (VFT), Boston Naming Test (BNT), Mini-Mental State Examination (MMSE), Word list memory (WLM), Word list recall (WLRecall) and Word list recognition (WLRecognition).  |  BNT scores were significantly lower in aMCI as compared with nondeficit schizophrenia. Moreover, it is known that education may contribute to cognitive reserve, which enhances resilience to brain damage by fostering more adequate cognitive strategies and a better exploitation of intact brain networks [48–50]. For more information about PLOS Subject Areas, click age and episodic memory scores of the core sample from Waves 3 to 12 and the final sample are similar. Approval for the study was obtained from the Institutional Review Board of the Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, which is in compliance with the International Guideline for Human Research protection as required by the Declaration of Helsinki, The Belmont Report, CIOMS Guideline and International Conference on Harmonization in Good Clinical Practice (ICH-GCP). A limitation of this study is its cross-sectional design, which precludes the establishment of firm causal inferences. Miguel Ángel Rivas-Fernández Laboratorio de Neurociencia Cognitiva, Departamento de Psicoloxía Clínica e Psicobioloxía, Universidade de … More specifically, the biosignature of memory impairments in (deficit) schizophrenia is highly significantly associated with activation of the tryptophan catabolite (TRYCAT) pathway and increased activity of neurotoxic TRYCATs, including picolinic and xanthurenic acid [18]. Roles 2008;13(1):45–53. Spatiotemporal pattern of brain electrical activity related to immediate and delayed episodic memory retrieval Neurobiol Learn Mem. Memory decline has been defined as a decrease of at least 1 SD from the mean change score on immediate recall (IR), delayed recall (DR), and retention, based on the AVLT (Dik, Jonker et al. https://doi.org/10.1371/journal.pone.0197004.g003. Regression analyses and machine learning procedures show that schizophrenia, and especially deficit schizophrenia, is best separated from aMCI using BNT and WLM scores as explanatory variables. -, Gauthier SR K. Does vascular MCI progress at a different rate than does amnestic MCI? WL False Recall was significantly higher in deficit schizophrenia than in the three other groups and higher in aMCI and nondeficit schizophrenia than in controls. Clesse C, Salime S, Dumand I, Concetta-Ciciarelli SB, Lavenir S, Kacemi K, Heckel-Chalet P, Sissung F, Poinsignon A, Simon A, Decker M, Batt M. Front Psychiatry. WL False Recall was significantly higher in the three patients groups as compared with controls and higher in deficit schizophrenia as compared with the three other groups, whilst there were no significant differences between nondeficit schizophrenia and aMCI. We used multivariate general linear model (GLM) analyses to delineate the effects of explanatory variables (diagnostic groups) on dependent variables (the CERAD data), while adjusting for age, sex and education. a) subjective memory complaints, b) abnormal memory for age, c) normal general cognitive function, d) preservation of functional activities, and e) absence of dementia". The authors would like to thank all participants and caregivers for their cooperation. TrueWLRecall: Word List Recall, Delayed, true recall; FalseWLRecall: Word List Recall, Delayed, false recall (WL False Recall); CorrectWLRecognition: WL Recognition Correct Yes response; NoWLRecognition: Word List Recognition Correct No response; WLRecognition: sum of Correctand No WLRecognition. Your memories of all those specific events and experiences are examples of episodic memory. 2019 Jul;23(7):840-850. doi: 10.1080/13607863.2018.1501668. WLRecCorrect and WLRec total were significantly lower in deficit schizophrenia than in the three other groups and lower in aMCI, but not nondeficit schizophrenia, than in controls. Yes In normal controls, GLM analyses (age-adjusted) show significantly higher MMSE (F = 4.38, df = 1/100, p = 0.039) and BNT (F = 10.95, df = 1/100, p<0.001) scores in men than women (MMSE: 28.63 ±0.42 versus 27.65 ±0.21 and BNT 13.84 ± 0.36 versus 12.49 ±0.18, respectively). The impairments in episodic memory, recall and recognition are more severe in younger patients with deficit schizophrenia as compared with elderly patients with aMCI, while aMCI patients show more dysnomia than patients with schizophrenia. However, because the effects on long-term and working memory were qualified by evidence for publication bias, we conclude that the effect of amphetamine and methylphenidate on the examined facets of … Epub 2020 Sep 2. 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